epstein-barr virus pcr analysis of serum and ocular swab samples in patients with inflammatory eye disease

background and aims: epstein-barr (ebv) virus infection is very common in the population. virus belongs to the family herpesviridae, whose representatives are characterized by the ability to cause the human body latent persistent infections. the goal of study is to assess ebv infection frequency and pcr method in the choice of ebv in inflammatory eye disease, comparing with ebv presence in eye infection and control group. materials and methods: primers were designed for conserved regions of the ebv genome. we have used pcr to rapid, accurate detection of ebv dna in blood and from eye swabs. we have chosen to study patients with eye inflammation or infection symptom. results: ebv dna was detectable in three 5 out of 130 control samples of serum (3.84%). ebv infection was seen in 1 out of 20 patients’ serum samples. compared with the controls, the presence of ebv dna was only significantly increased in samples of the patient group. 3 out of 20 patients in patients and 2 out of 130 of control group had detectable ebv dna in their ocular swab. conclusion: we have presented evidence for the presence of ebv sequences in normal and eye inflammation samples with pcr.  ebv serology was available for large number of individuals. the prevalence of ebv in ocular disease samples varied dramatically that this wide range may be due to variations and inconsistency in the techniques used to detect the virus and its components, as well as geography and genetic susceptibility.